Welcome to the Research Pages of
Hans J. Reich

Hans J. Reich

Organic and organometallic chemistry
Organolithium structure and reactivity
NMR Spectroscopy
Stereochemistry

1101 University Avenue
Department of Chemistry
University of Wisconsin
Madison, WI 53706, USA
Tel: (608) 262-5794 Fax: (608)262-0381

Recent Papers

Tris(trimethylsilyl)methane as an Internal ¹³C NMR Chemical Shift Thermometer, Sikorski, Sanders, Reich, Magn. Resonan. Chem. 1998, 36, S118. PDF.
Triple Ion Formation in Localized Organolithium Reagents, Reich, Sikorski, Gudmundsson, Dykstra, J. Am. Chem. Soc. 1998, 120, 4035. PDF.
Aggregation and Reactivity of Phenyllithium Solutions, Reich, Green, Medina, Goldenberg, Gudmundsson, Dykstra, Phillips, J. Am. Chem. Soc. 1998, 120, 7201. (Article) PDF, Suppl.
Solution Structure and Stereochemistry of Alkyl- and Silyl-Substituted Allenyl-Propargyllithium Reagents, Reich, Holladay, Walker, Thompson, J. Am. Chem. Soc. 1999, 121, 9769. (Article) PDF.
Solvent-Dependent Lithium-Bridging in Allenyl- Propargyllithium Reagents, Reich, Thompson, Org. Letters 2000, 2, 783. (Communication) PDF.
The Regioselectivity of Addition of Organolithium Reagents to Enones: The Role of HMPA, Sikorski, Reich, J. Am. Chem. Soc. 2001, 123, 6527-6535.(Article) PDF Suppl; J. Org. Chem. 1999, 64, 14. (Commun) PDF.
Amine-Chelated Aryllithium Reagents - Structure and Dynamics, Reich, Goldenberg, Gudmundsson, Sanders, Kulicke, Simon, Guzei J. Am. Chem. Soc. 2001, 123, 8067-8079. (Article) PDF, Suppl.
Are Ate Complexes True Intermediates in Lithium-Metalloid exchange? Subtle Effects of Ion-Pair Structure in Lithium-Tellurium and Lithium-Selenium Exchange Reactions, Reich, Bevan, Gudmundsson, Puckett, Angew. Chem. Int. Ed. Engl. 2002, 41, 3436-3439. (Communication) PDF.
The Effect of HMPA on the Reactivity of Epoxides, Aziridines and Alkyl Halides with Organolithium Reagents, Reich, Sanders, Fiedler, Bevan, J. Am. Chem. Soc. 2002, 124, 13386-13387. (Communication) PDF, Suppl.
The Role of Ate Complexes in the Lithium-Sulfur, Lithium-Selenium and Lithium-Tellurium Exchange Reactions, Reich, Gudmundsson, Green, Bevan, Reich, Helv. Chim. Acta 2002, 85, 3748-3772. (Article) PDF.
Amine and Ether Chelated Aryllithium Reagents -- Ring Size and Chelating Group Effects, Reich, Goldenberg, Sanders, Jantzi, Tzschucke, J. Am. Chem. Soc 2003, 125, 3509. (Article) PDF-Full, Suppl, Comm.
Reaction of Metalated Nitriles with Enones, Reich, Biddle, Edmonston J. Org. Chem. 2005, 70, 3375-3382. (Article) PDF, Suppl.
Mechanism of the Lithium-Iodine Exchange in an Iodothiophene, Reich, Whipple, Can. J. Chem. 2005, 83, 1577. PDF
Solution Structure and Chelation Properties of 2-Thienyllithium Reagents, Jantzi, Puckett, Guzei, Reich, J. Org. Chem. 2005, 70,7520-7529. (Article) PDF, Suppl.
Interconversion of Contact and Separated Ion Pairs in Silyl- and Arylthio-Substituted Alkyllithium Reagents, Reich, Sikorski, Thompson, Sanders, Jones, Org. Lett. 2006, 8, 4003-4006. (Communication) PDF
Studies on the Reactive Species in Fluoride-Mediated Carbon-Carbon Bond-Forming Reactions: Carbanion Formation by Desilylation with Fluoride and Enolates, Biddle, Reich, J. Org. Chem. 2006, 71, 4031-4039.(Article) PDF Suppl., JOC Cover
Solution and Solid-State Structures of Lithiated Phenyloxazolines, Jantzi,Guzei, Reich, Organometallics. 2006, 25, 5380. (Article) PDF Suppl.
Reactivity of Individual Organolithium Aggregates - a RINMR Study of n-Butyllithium and 2-Methoxy-6-(methoxymethyl)phenyllithium, Jones, Sanders, Bevan Reich, J. Am. Chem. Soc. 2007, 129, 3492-3493. (Communication). PDF, Suppl.
Reactivity of the Triple Ion and Separated Ion Pair of Tris(trimethylsilyl)methyllithium with Aldehydes: A RINMR Study, Jones, Sanders, Sikorski, Jansen, Reich, J. Am. Chem. Soc. 2008, 130, 6060-6061 (Communication). PDF, Suppl, DOI
Stabilization of Ketone and Aldehyde Enols by Formation of Hydrogen Bonds to Phosphazene Enolates and Their Aldol Products, Kolonko, Reich J. Am. Chem. Soc. 2008, 130, 9668 (Communication) PDF, Suppl, DOI
Multinuclear NMR Study of the Solution Structure and Reactivity of Tris(trimethylsilyl)methyllithium and its Iodine Ate Complex, Reich, Sikorski, Sanders, Jones, Plessel J. Org. Chem. 2009, 74, 719 (Article) PDF, Suppl, DOI
Solution Structures of Lithium Enolates of Cyclopentanone, Cyclohexanone, Acetophenones, and Benzyl Ketones. Triple Ions and Higher Lithiate Complexes, Kolonko, Biddle, Guzei, Reich J. Am. Chem. Soc. 2009, 131, 15525 (Article) PDF, Suppl, DOI
Structure and Dynamics of α-Aryl Amide and Ketone Enolates: THF, PMDTA, TMTAN, HMPA, and Crypt-Solvated Lithium Enolates, and Comparison with Phosphazenium Analogues Kolonko, Guzei, Reich J. Org. Chem. 2010, 75, 6163-6172. (Article) PDF, Suppl, DOI
Mechanistic Studies of the Lithium Enolate of 4-Fluoroacetophenone: Rapid-Injection NMR Study of Enolate Formation, Dynamics, and Aldol Reactivity Kolonko, Wherritt, Reich J. Am. Chem. Soc. 2011, 133, 16774-16777. (Communication) PDF, Suppl, DOI
What's Going on with These Lithium Reagents? Reich J. Org. Chem. 2012, 77, 5471-5491. (Review) PDF, DOI, JOC Cover
Role of Organolithium Aggregates and Mixed Aggregates in Organolithium Mechanisms Reich Chem. Rev. 2013, 113, 7130-7178. (Review) PDF, DOI
A Rapid Injection NMR Study of the Reaction of Organolithium Reagents with Esters, Amides, and Ketones. Plessel, Jones, Wherritt, Maksymowicz, Poweleit, Reich Org. Lett., 2015, 17, 2310-2313. (Communication) PDF, Suppl, DOI ACS Editor's Choice
Why Nature Chose Selenium Reich, Hondal ACS Chem. Biol. 2016, 11, 821-841. (Review) PDF, DOI
Chiral hemicucurbit[8]uril as an anion receptor: selectivity to size, shape and charge distribution Kaabel, Adamson, Topic, Kiesil, Oeren, Reimund, Prigorchenko, Lookene, Reich, Rissanen, Aav RSC Chem.Sciene 2016 PDF, DOI

Full Publications List · Most cited paper (JACS 1975, 97, 5434)

Biography


1960 - 1964	B. Sc. with Prof. Karl Kopecky at University of Alberta - Edmonton

1964 - 1968	Ph. D. with Prof. D. J. Cram, UCLA

1968 - 1969	Postdoc with Prof. J. D. Roberts, California Institute of Technology

1969 - 1970	Postdoc with Prof. R. B. Woodward Harvard University

1970-	Professor of Chemistry - University of Wisconsin, Madison

1979	Visiting Professor University in Marburg, Germany with Prof. Reinhard Hoffmann
1987	Visiting Professor University of Strasbourg, France with Prof. Francois Biellmann
1997	Visiting Professor University of Alicante, Spain with Prof. Miguel Yus

Hobbies: Nature-photography; Programming:PLT; DNMR Scuba Diving

Reich Home · Research Description · Full Publications List · Organic Chemistry Info