| Pittsburgh Analytical Chemistry Award | Lloyd M. Smith |
| Fellow, American Association for the Advancement of Science | Lloyd M. Smith |
| W. L. Hubbell Professorship, University of Wisconsin-Madison | Lloyd M. Smith |
| Member, Faculty of 1000 | Lloyd M. Smith |
| Joy Goodwin Lecturer, Auburn University | Lloyd M. Smith |
| Vilas Associate Award, 2008-2010 | Lloyd M. Smith |
| American Chemical Society Award in Chemical Instrumentation | Lloyd M. Smith |
| John D. MacArthur Professorship, University of Wisconsin-Madison | Lloyd M. Smith |
| WARF Kellett Mid-Career Faculty Researcher Award, University of Wisconsin- Madison, 1999-2004 | Lloyd M. Smith |
| Association of Biomolecular Resource Facilities Award for Development of Automated DNA Sequencing | Lloyd M. Smith |
| WARF Romnes Faculty Fellowship, University of Wisconsin-Madison | Lloyd M. Smith |
| Inaugural Speaker, Kazusa DNA Research Institute, Japan | Lloyd M. Smith |
| Research Scholar Lecturer, Drew University, NJ | Lloyd M. Smith |
| Eli Lilly Analytical Chemistry Award | Lloyd M. Smith |
| National Science Foundation Presidential Young Investigator Award | Lloyd M. Smith |
| Science Digest's Top 100 Innovators | Lloyd M. Smith |
| National Institute of Health Postdoctoral Trainee | Lloyd M. Smith |
| National Institute of Health Predoctoral Trainee | Lloyd M. Smith |
| Honors in Biochemistry, University of California-Berkeley | Lloyd M. Smith |