Department of Chemistry

College of Letters & Science
De Luca G, Fochesato S, Lavergne J, Forest KT, Barakat M, Ortet P, et al.. Light on the cell cycle of the non-photosynthetic bacterium Ramlibacter tataouinensis. Scientific Reports. 2019;9.
Craig L, Forest KT, Maier B. Type IV pili: dynamics, biophysics and functional consequences. Nature Reviews Microbiology. 2019;17:429-440.
Kurgan KW, Kleman AF, Bingman CA, Kreitler DF, Weisblum B, Forest KT, et al.. Retention of Native Quaternary Structure in Racemic Melittin Crystals. Journal of the American Chemical Society. 2019;141:7704-7708.
Kreitler DF, Yao ZH, Steinkruger JD, Mortenson DE, Huang LJ, Mittal R, et al.. A Hendecad Motif Is Preferred for Heterochiral Coiled-Coil Formation. Journal of the American Chemical Society. 2019;141:1583-1592.
Yao ZH, Cary BP, Bingman CA, Wang CX, Kreitler DF, Satyshur KA, et al.. Use of a Stereochemical Strategy To Probe the Mechanism of Phenol-Soluble Modulin alpha 3 Toxicity. Journal of the American Chemical Society. 2019;141:7660-7664.
Dwulit-Smith JR, Hamilton JJ, Stevenson DM, He S, Oyserman BO, Moya-Flores F, et al.. acI Actinobacteria Assemble a Functional Actinorhodopsin with Natively Synthesized Retinal. Applied and Environmental Microbiology. 2018;84.
Windsor IW, Palte MJ, Lukesh JC, Gold B, Forest KT, Raines RT. Sub-picomolar Inhibition of HIV-1 Protease with a Boronic Acid. Journal of the American Chemical Society. 2018;140:14015-14018.
Mortenson DE, Kreitler DF, Thomas NC, Guzei IA, Gellman SH, Forest KT. Evaluation of -Amino Acid Replacements in Protein Loops: Effects on Conformational Stability and Structure. Chembiochem. 2018;19:604-612.
Goosens VJ, Busch A, Georgiadou M, Castagnini M, Forest KT, Waksman G, et al.. Reconstitution of a minimal machinery capable of assembling periplasmic type IV pili. Proceedings of the National Academy of Sciences of the United States of America. 2017;114:E4978-E4986.
Wangkanont K, Winton VJ, Forest KT, Kiessling LL. Conformational Control of UDP-Galactopyranose Mutase Inhibition. Biochemistry. 2017;56:3983-3992.
Smith TP, Windsor IW, Forest KT, Raines RT. Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation. Journal of Medicinal Chemistry. 2017;60:7820-7834.
Hamilton JJ, Garcia SL, Brown BS, Oyserman BO, Moya-Flores F, Bertilsson S, et al.. Metabolic network analysis and metatranscriptomics reveal auxotrophies and nutrient sources of the cosmopolitan freshwater microbial lineage acI. Msystems. 2017;2.
Douzi B, Trinh NTT, Michel-Souzy S, Desmyter A, Ball G, Barbier P, et al.. Unraveling the self-assembly of the pseudomonas aeruginosa XcpQ secretin periplasmic domain provides new molecular insights into type II secretion system secreton architecture and dynamics. Mbio. 2017;8.
Baker AW, Satyshur KA, Morales NM, Forest KT. Arm-in-Arm Response Regulator Dimers Promote Intermolecular Signal Transduction. Journal of Bacteriology. 2016;198:1218-1229.
Forest KT, Stock AM. Classic Spotlight: Crowd Sourcing Provided Penicillium Strains for the War Effort. Journal of BacteriologyJournal of Bacteriology. 2016;198:877-877.
Kreitler DF, Mortenson DE, Forest KT, Gellman SH. Effects of Single alpha-to-beta Residue Replacements on Structure and Stability in a Small Protein: Insights from Quasiracemic Crystallization. Journal of the American Chemical Society. 2016;138:6498-6505.
Wangkanont K, Wesener DA, Vidani JA, Kiessling LL, Forest KT. Structures of Xenopus Embryonic Epidermal Lectin Reveal a Conserved Mechanism of Microbial Glycan Recognition. Journal of Biological Chemistry. 2016;291:5596-5610.
Kincaid VA, London N, Wangkanont K, Wesener DA, Marcus SA, Heroux A, et al.. Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents. ACS Chemical Biology. 2015;10:2209-2218.
Mortenson DE, Steinkruger JD, Kreitler DF, Perroni DV, Sorenson GP, Huang L, et al.. High-resolution structures of a heterochiral coiled coil. Proceedings of the National Academy of Sciences of the United States of America. 2015;112:13144-13149.
Wangkanont K, Forest KT, Kiessling LL. The non-detergent sulfobetaine-201 acts as a pharmacological chaperone to promote folding and crystallization of the type II TGF-beta receptor extracellular domain. Protein Expression and Purification. 2015;115:19-25.
Hayouka Z, Thomas NC, Mortenson DE, Satyshur KA, Weisblum B, Forest KT, et al.. Quasiracemate Crystal Structures of Magainin 2 Derivatives Support the Functional Significance of the Phenylalanine Zipper Motif. Journal of the American Chemical Society. 2015;137:11884-7.
Lehtivuori H, Bhattacharya S, Angenent-Mari NM, Satyshur KA, Forest KT. Removal of Chromophore-Proximal Polar Atoms Decreases Water Content and Increases Fluorescence in a Near Infrared Phytofluor. Front Mol Biosci. 2015;2:65.
Wesener DA, Wangkanont K, McBride R, Song XZ, Kraft MB, Hodges HL, et al.. Recognition of microbial glycans by human intelectin-1. Nature Structural & Molecular Biology. 2015;22:603-610.
Checco JW, Kreitler DF, Thomas NC, Belair DG, Rettko NJ, Murphy WL, et al.. Targeting diverse protein-protein interaction interfaces with alpha/beta-peptides derived from the Z-domain scaffold. Proceedings of the National Academy of Sciences of the United States of America. 2015;112:4552-4557.
Park H, Kevany BM, Dyer DH, Thomas MG, Forest KT. A Polyketide Synthase Acyltransferase Domain Structure Suggests a Recognition Mechanism for Its Hydroxymalonyl-Acyl Carrier Protein Substrate. Plos One. 2014;9:10.
Hastie JL, Williams KB, Sepulveda C, Houtman JC, Forest KT, Ellermeier CD. Evidence of a Bacterial Receptor for Lysozyme: Binding of Lysozyme to the Anti-sigma Factor RsiV Controls Activation of the ECF sigma Factor sigma(V). Plos Genetics. 2014;10:16.
Ghylin TW, Garcia SL, Moya F, Oyserman BO, Schwientek P, Forest KT, et al.. Comparative single-cell genomics reveals potential ecological niches for the freshwater acl Actinobacteria lineage. ISME Journal. 2014;8:2503-2516.
Forest KT. Vivid watercolor paintbox for eukaryotic algae. Proceedings of the National Academy of Sciences of the United States of America. 2014;111:5448-5449.
Baker AW, Forest KT. Structural Biology: Action at a distance in a light receptor. NatureNature. 2014;509:174-175.
Bhattacharya S, Auldridge ME, Lehtivuori H, Ihalainen JA, Forest KT. Origins of Fluorescence in Evolved Bacteriophytochromes. Journal of Biological Chemistry. 2014;289:32144-32152.
Nieder JB, Stojkovic EA, Moffat K, Forest KT, Lamparter T, Bittl R, et al.. Pigment-Protein Interactions in Phytochromes Probed by Fluorescence Line Narrowing Spectroscopy. Journal of Physical Chemistry B. 2013;117:14940-14950.
Aly KA, Beebe ET, Chan CH, Goren MA, Sepulveda C, Makino S, et al.. Cell-free production of integral membrane aspartic acid proteases reveals zinc-dependent methyltransferase activity of the Pseudomonas aeruginosa prepilin peptidase PilD. Microbiologyopen. 2013;2:94-104.
Mortenson DE, Kreitler DF, Yun HG, Gellman SH, Forest KT. Evidence for small-molecule-mediated loop stabilization in the structure of the isolated Pin1 WW domain. Acta Crystallographica Section D-Biological Crystallography. 2013;69:2506-2512.
Shin YH, Mortenson DE, Satyshur KA, Forest KT, Gellman SH. Differential Impact of beta and gamma Residue Preorganization on alpha/beta/gamma-Peptide Helix Stability in Water. Journal of the American Chemical Society. 2013;135:8149-8152.
Forest KT. Enterotoxigenic Escherichia coli CS1 Pilus: Not One Structure but Several. Journal of Bacteriology. 2013;195:1357-1359.
Hayouka Z, Mortenson DE, Kreitler DF, Weisblum B, Forest KT, Gellman SH. Evidence for Phenylalanine Zipper-Mediated Dimerization in the X-ray Crystal Structure of a Magainin 2 Analogue. Journal of the American Chemical Society. 2013;135:15738-15741.
Auldridge ME, Satyshur KA, Anstrom DM, Forest KT. Structure-guided Engineering Enhances a Phytochrome-based Infrared Fluorescent Protein. Journal of Biological Chemistry. 2012;287:7000-7009.
McLaughlin LS, Haft RJF, Forest KT. Structural insights into the Type II secretion nanomachine. Current Opinion in Structural Biology. 2012;22:208-216.
Mortenson DE, Satyshur KA, Guzei IA, Forest KT, Gellman SH. Quasiracemic Crystallization as a Tool To Assess the Accommodation of Noncanonical Residues in Nativelike Protein Conformations. Journal of the American Chemical Society. 2012;134:2473-2476.
Cordes TJ, Worzalla GA, Ginster AM, Forest KT. Crystal Structure of the Pseudomonas aeruginosa Virulence Factor Regulator. Journal of Bacteriology. 2011;193:4069-4074.
Franz LP, Douzi B, Durand E, Dyer DH, Voulhoux R, Forest KT. Structure of the minor pseudopilin XcpW from the Pseudomonas aeruginosa type II secretion system. Acta Crystallographica Section D-Biological Crystallography. 2011;67:124-130.
Auldridge ME, Forest KT. Bacterial phytochromes: More than meets the light. Critical Reviews in Biochemistry and Molecular Biology. 2011;46:67-88.
Shoulders MD, Satyshur KA, Forest KT, Raines RT. Stereoelectronic and steric effects in side chains preorganize a protein main chain. Proceedings of the National Academy of Sciences of the United States of America. 2010;107:559-564.
Misic AM, Satyshur KA, Forest KT. P. aeruginosa PilT Structures with and without Nucleotide Reveal a Dynamic Type IV Pilus Retraction Motor. Journal of Molecular Biology. 2010;400:1011-1021.
Gruber TD, Westler WM, Kiessling LL, Forest KT. X-ray Crystallography Reveals a Reduced Substrate Complex of UDP-Galactopyranose Mutase Poised for Covalent Catalysis by Flavin. Biochemistry. 2009;48:9171-9173.
Gruber TD, Borrok MJ, Westler WM, Forest KT, Kiessling LL. Ligand Binding and Substrate Discrimination by UDP-Galactopyranose Mutase. Journal of Molecular Biology. 2009;391:327-340.
Mikaty G, Soyer M, Mairey E, Henry N, Dyer D, Forest KT, et al.. Extracellular Bacterial Pathogen Induces Host Cell Surface Reorganization to Resist Shear Stress. Plos Pathogens. 2009;5:14.
Bornschlogl T, Anstrom DM, Mey E, Dzubiella J, Rief M, Forest KT. Tightening the Knot in Phytochrome by Single-Molecule Atomic Force Microscopy. Biophysical Journal. 2009;96:1508-1514.
Borrok MJ, Zhu YM, Forest KT, Kiessling LL. Structure-Based Design of a Periplasmic Binding Protein Antagonist that Prevents Domain Closure. ACS Chemical Biology. 2009;4:447-456.
Dagenais TR, Demick KP, Bangs JD, Forest KT, Paulnock DM, Mansfield JM. T-Cell Responses to the Trypanosome Variant Surface Glycoprotein Are Not Limited to Hypervariable Subregions. Infection and Immunity. 2009;77:141-151.
Dyer DH, Vyazunova I, Lorch JM, Forest KT, Lan Q. Characterization of the yellow fever mosquito sterol carrier protein-2 like 3 gene and ligand-bound protein structure. Molecular and Cellular Biochemistry. 2009;326:67-77.
Cordes TJ, Carlson CB, Forest KT. Tonal Interface to MacroMolecules (TIMMol). Biochemistry and Molecular Biology Education. 2008;36:203-208.
Wagner JR, Zhang JR, von Stetten D, Guenther M, Murgida DH, Mroginski MA, et al.. Mutational analysis of Deinococcus radiodurans bacteriophytochrome reveals key amino acids necessary for the photochromicity and proton exchange cycle of phytochromes. Journal of Biological Chemistry. 2008;283:12212-12226.
von Stetten D, Gunther M, Scheerer P, Murgida DH, Mroginski MA, Krauss N, et al.. Chromophore heterogeneity and photoconversion in phytochrome crystals and solution studied by resonance Raman spectroscopy. Angewandte Chemie-International Edition. 2008;47:4753-4755.
Dyer DH, Wessely V, Forest KT, Lan Q. Three-dimensional structure/function analysis of SCP-2-like2 reveals differences among SCP-2 family members. Journal of Lipid Research. 2008;49:644-653.
Forest KT. The type II secretion arrowhead: the structure of GspI-GspJ-GspK. Nature Structural & Molecular Biology. 2008;15:428-430.
Wagner JR, Zhang JR, Brunzelle JS, Vierstra RD, Forest KT. High resolution structure of Deinococcus bacteriophytochrome yields new insights into phytochrome architecture and evolution. Journal of Biological Chemistry. 2007;282:12298-12309.
Helaine S, Dyer DH, Nassif X, Pelicic V, Forest KT. 3D structure/function analysis of PiIX reveals how minor pilins can modulate the virulence properties of type IV pili. Proceedings of the National Academy of Sciences of the United States of America. 2007;104:15888-15893.
Satyshur KA, Worzalla GA, Meyer LS, Heiniger EK, Aukema KG, Misic AM, et al.. Crystal structures of the pilus retraction motor PilT suggest large domain movements and subunit cooperation drive motility. Structure. 2007;15:363-376.
Hansen JK, Demick KP, Mansfield JM, Forest KT. Conserved regions from Neisseria gonorrhoeae pilin are immunosilent and not immunosuppressive. Infection and Immunity. 2007;75:4138-4147.
Borrok JM, Kiessling LL, Forest KT. Conformational changes of glucose/galactose-binding protein illuminated by open, unliganded, and ultra-high-resolution ligand-bound structures. Protein Science. 2007;16:1032-1041.
Hansen JK, Forest KT. Type IV pilin structures: Insights on shared architecture, fiber assembly, receptor binding and type II secretion. Journal of Molecular Microbiology and Biotechnology. 2006;11:192-207.
Aukema KG, Kron EM, Herdendorf TJ, Forest KT. Functional dissection of a conserved motif within the pilus retraction protein PilT. Journal of Bacteriology. 2005;187:611-618.
Wagner JR, Brunzelle JS, Forest KT, Vierstra RD. A light-sensing knot revealed by the structure of the chromophore-binding domain of phytochrome. Nature. 2005;438:325-331.
Forest KT, Satyshur KA, Worzalla GA, Hansen JK, Herdendorf TJ. The pilus-retraction protein the biological assembly PilT: ultrastructure of the biological assembly. Acta Crystallographica Section D-Biological Crystallography. 2004;60:978-982.
Forest KT, Filutowicz MS. Remodeling of replication initiator proteins. Nature Structural Biology. 2003;10:496-498.
Craig L, Taylor RK, Pique ME, Adair BD, Arvai AS, Singh M, et al.. Type IV pilin structure and assembly: X-ray and EM analyses of Vibrio cholerae toxin-coregulated pilus and Pseudomonas aeruginosa PAK pilin. Molecular Cell. 2003;11:1139-1150.
Merz AJ, Forest KT. Bacterial surface motility: Slime trails, grappling hooks and nozzles. Current Biology. 2002;12:R297-R303.
Herdendorf TJ, McCaslin DR, Forest KT. Aquifex aeolicus PilT, homologue of a surface motility protein, is a thermostable oligomeric NTPase. Journal of Bacteriology. 2002;184:6465-6471.
Forest KT, Langford PR, Kroll JS, Getzoff ED. Cu,Zn superoxide dismutase structure from a microbial pathogen establishes a class with a conserved dimer interface. Journal of Molecular Biology. 2000;296:145-153.
Forest KT, Dunham SA, Koomey M, Tainer JA. Crystallographic structure reveals phosphorylated pilin from Neisseria: phosphoserine sites modify type IV pilus surface chemistry and fibre morphology. Molecular Microbiology. 1999;31:743-752.
Lane M, Bavister BD, Lyons EA, Forest KT. Containerless vitrification of mammalian oocytes and embryos - Adapting a proven method for flash-cooling protein crystals to the cryopreservation of live cells. Nature Biotechnology. 1999;17:1234-1236.
Forest KT, Tainer JA. Type IV pilin structure, assembly and immunodominance: Applications to vaccine design. In: Brown F, Burton D, Doherty P, Mekalanos J, Norrby E. Plainview: Cold Spring Harbor Laboratory Press; 1997. pp. 167-173.
Forest KT, Tainer JA. Type-4 pilus-structure: Outside to inside and top to bottom - A minireview. Gene. 1997;192:165-169.
Forest KT, Bernstein SL, Getzoff ED, So M, Tribbick G, Geysen HM, et al.. Assembly and antigenicity of the Neisseria gonorrhoeae pilus mapped with antibodies. Infection and Immunity. 1996;64:644-652.
Parge HE, Forest KT, Hickey MJ, Christensen DA, Getzoff ED, Tainer JA. STRUCTURE OF THE FIBER-FORMING PROTEIN PILIN AT 2.6-ANGSTROM RESOLUTION. Nature. 1995;378:32-38.