Department of Chemistry

College of Letters & Science
Hoover BM, Shen ZZ, Gahan CG, Lynn DM, Van Lehn RC, Murphy RM. Membrane Remodeling and Stimulation of Aggregation Following alpha-Synuclein Adsorption to Phosphotidylserine Vesicles. 2021;125:1582-1594.
Agarwal H, Nyffeler KE, Manna U, Blackwell HE, Lynn DM. Liquid Crystal-Infused Porous Polymer Surfaces: A "Slippery" Soft Material Platform for the Naked-Eye Detection and Discrimination of Amphiphilic Species. ACS Applied Materials & Interfaces. 2021;13:33652-33663.
Ortiz BJ, Jennings J, Gross WS, Santos TMA, Lin TY, Weibel DB, et al.. Soft Materials that Intercept, Respond to, and Sequester Bacterial Siderophores. 2021;33:5401-5412.
Gahan CG, Patel SJ, Chen LM, Manson DE, Ehmer ZJ, Blackwell HE, et al.. Bacterial Quorum Sensing Signals Promote Large-Scale Remodeling of Lipid Membranes. Langmuir. 2021;37:9120-9136.
Gahan CG, Patel SJ, Boursier ME, Nyffeler KE, Jennings J, Abbott NL, et al.. Bacterial Quorum Sensing Signals Self-Assemble in Aqueous Media to Form Micelles and Vesicles: An Integrated Experimental and Molecular Dynamics Study. 2020;124:3616-3628.
Ortiz BJ, Boursier ME, Barrett KL, Manson DE, Amador-Noguez D, Abbott NL, et al.. Liquid Crystal Emulsions That Intercept and Report on Bacterial Quorum Sensing. ACS Applied Materials & Interfaces. 2020;12:29056-29065.
Carter MCD, Wong MS, Wang FR, Lynn DM. Influence of Side Chain Hydrolysis on the Evolution of Nanoscale Roughness and Porosity in Amine-Reactive Polymer Multilayers. 2020;32:6935-6946.
Lee MR, Raman N, Ortiz-Bermudez P, Lynn DM, Palecek SP. 14-Helical beta-Peptides Elicit Toxicity against C. albicans by Forming Pores in the Cell Membrane and Subsequently Disrupting Intracellular Organelles. Cell Chemical Biology. 2019;26:289-+.
Abbasi R, Jain R, Nelson K, Busche D, Lynn DM, Abbott NL. Polymeric Films Containing Sodium Chlorite That Release Disinfectant Gas upon Activation with UV Light. Advanced Functional Materials. 2019;29.
Lopez ADR, Lee MR, Ortiz BJ, Gastfriend BD, Whitehead R, Lynn DM, et al.. Preventing S. aureus biofilm formation on titanium surfaces by the release of antimicrobial beta-peptides from polyelectrolyte multilayers. Acta Biomaterialia. 2019;93:50-62.
De Bruyn M, Cuello-Penaloza P, Cendejas M, Hermans I, He JY, Krishna SH, et al.. Hexane-1,2,5,6-tetrol as a Versatile and Biobased Building Block for the Synthesis of Sustainable (Chiral) Crystalline Mesoporous Polyboronates. Acs Sustainable Chemistry & Engineering. 2019;7:13430-13436.
Lopez A, Lee MR, Wang NB, Dunn KK, Sanchez H, Raman N, et al.. Small-Molecule Morphogenesis Modulators Enhance the Ability of 14-Helical beta-Peptides To Prevent Candida albicans Biofilm Formation. Antimicrobial Agents and Chemotherapy. 2019;63.
Guo XR, Gonzalez KS, Lynn DM. Templated Synthesis of Polymer-Based Yolk/Shell Particles with Tunable Morphologies. Chemistry of Materials. 2019;31:7443-7452.
Jain R, Abbasi R, Nelson K, Busche D, Lynn DM, Abbott NL. Generation of Gaseous ClO2 from Thin Films of Solid NaClO2 by Sequential Exposure to Ultraviolet Light and Moisture. ACS Applied Materials & Interfaces. 2017;9:16594-16603.
Kratochvil MJ, Carter MCD, Lynn DM. Amine-Reactive Azlactone-Containing Nanofibers for the Immobilization and Patterning of New Functionality on Nanofiber-Based Scaffolds. ACS Applied Materials & Interfaces. 2017;9:10243-10253.
Kratochvil MJ, Yang T, Blackwell HE, Lynn DM. Nonwoven Polymer Nanofiber Coatings That Inhibit Quorum Sensing in Staphylococcus aureus: Toward New Nonbactericidal Approaches to Infection Control. Acs Infectious Diseases. 2017;3:271-280.
Zayas-Gonzalez YM, Ortiz BJ, Lynn DM. Layer-by-Layer Assembly of Amine-Reactive Multilayers Using an Azlactone-Functionalized Polymer and Small-Molecule Diamine Linkers. Biomacromolecules. 2017;18:1499-1508.
Kratochvil MJ, Manna U, Lynn DM. Superhydrophobic Polymer Multilayers for the Filtration- and Absorption-Based Separation of Oil/Water Mixtures. Journal of Polymer Science Part a-Polymer Chemistry. 2017;55:3127-3136.
Lee MR, Raman N, Gellman SH, Lynn DM, Palecek SP. Incorporation of beta-Amino Acids Enhances the Antifungal Activity and Selectivity of the Helical Antimicrobial Peptide Aurein 1.2. ACS Chemical Biology. 2017;12:2975-2980.
Holden MT, Carter MCD, Ting SK, Lynn DM, Smith LM. Parallel DNA Synthesis on Poly(ethylene terephthalate). Chembiochem. 2017;18:1914-1916.
Carter MCD, Jennings J, Appadoo V, Lynn DM. Synthesis and Characterization of Backbone Degradable Azlactone-Functionalized Polymers. Macromolecules. 2016;49:5514-5526.
Jain R, Faith NG, Milkowski A, Nelson K, Busche D, Lynn DM, et al.. Using Chemoattractants to Lure Bacteria to Contact-Killing Surfaces. Angewandte Chemie-International Edition. 2016;55:5698-5702.
Manna U, Raman N, Welsh MA, Zayas-Gonzalez YM, Blackwell HE, Palecek SP, et al.. Slippery Liquid-Infused Porous Surfaces that Prevent Microbial Surface Fouling and Kill Non-Adherent Pathogens in Surrounding Media: A Controlled Release Approach. Advanced Functional Materials. 2016;26:3599-3611.
Kratochvil MJ, Welsh MA, Manna U, Ortiz BJ, Blackwell HE, Lynn DM. Slippery Liquid-Infused Porous Surfaces that Prevent Bacterial Surface Fouling and Inhibit Virulence Phenotypes in Surrounding Planktonic Cells. Acs Infectious Diseases. 2016;2:509-517.
Carter MCD, Lynn DM. Covalently Crosslinked and Physically Stable Polymer Coatings with Chemically Labile and Dynamic Surface Features Fabricated by Treatment of Azlactone-Containing Multilayers with Alcohol-, Thiol-, and Hydrazine-Based Nucleophiles. Chemistry of Materials. 2016;28:5063-5072.
Carter MCD, Jennings J, Speetjens FW, Lynn DM, Mahanthappa MK. A Reactive Platform Approach for the Rapid Synthesis and Discovery of High chi/Low N Block Polymers. Macromolecules. 2016;49:6268-6276.
Zayas-Gonzalez YM, Lynn DM. Degradable Amine-Reactive Coatings Fabricated by the Covalent Layer-by-Layer Assembly of Poly(2-vinyl-4,4-dimethylazlactone) with Degradable Polyamine Building Blocks. Biomacromolecules. 2016;17:3067-3075.
Raman N, Lee MR, Lopez ADR, Palecek SP, Lynn DM. Antifungal activity of a beta-peptide in synthetic urine media: Toward materials-based approaches to reducing catheter-associated urinary tract fungal infections. Acta Biomaterialia. 2016;43:240-250.
Choi JW, Carter MCD, Wei W, Kanimozi C, Speetjens FW, Mahanthappa MK, et al.. Self-Assembly and Post-Fabrication Functionalization of Microphase Separated Thin Films of a Reactive Azlactone-Containing Block, Copolymer. Macromolecules. 2016;49:8177-8186.
Raman N, Marchillo K, Lee M-R, Lopez Ade LRodr, Andes DR, Palecek SP, et al.. Intraluminal Release of an Antifungal β-Peptide Enhances the Antifungal and Anti-Biofilm Activities of Multilayer-Coated Catheters in a Rat Model of Venous Catheter Infection. ACS Biomater. Sci. Eng. 2016;2:112-121.
Appadoo V, Carter MCD, Lynn DM. Controlling the surface-mediated release of DNA using 'mixed multilayers'. Bioeng. Transl. Med. 2016;1:181-192.
Manna U, Lynn DM. Fabrication of Liquid-Infused Surfaces Using Reactive Polymer Multilayers: Principles for Manipulating the Behaviors and Mobilities of Aqueous Fluids on Slippery Liquid Interfaces. Advanced Materials. 2015;27:3007-3012.
Yu Y, Si Y, Bechler SL, Liu B, Lynn DM. Polymer Multilayers that Promote the Rapid Release and Contact Transfer of DNA. Biomacromolecules. 2015;16:2998-3007.
Holden MT, Carter MCD, Wu CH, Wolfer J, Codner E, Sussman MR, et al.. Photolithographic Synthesis of High-Density DNA and RNA Arrays on Flexible, Transparent, and Easily Subdivided Plastic Substrates. Analytical Chemistry. 2015;87:11420-11428.
Carter MCD, Miller DS, Jennings J, Wang XG, Mahanthappa MK, Abbott NL, et al.. Synthetic Mimics of Bacterial Lipid A Trigger Optical Transitions in Liquid Crystal Microdroplets at Ultra low Picogram-per-Milliliter Concentrations. Langmuir. 2015;31:12850-12855.
Guo XR, Manna U, Abbott NL, Lynn DM. Covalent Immobilization of Caged Liquid Crystal Microdroplets on Surfaces. ACS Applied Materials & Interfaces. 2015;7:26892-26903.
Manna U, Lynn DM. Synthetic Surfaces with Robust and Tunable Underwater Superoleophobicity. Advanced Functional Materials. 2015;25:1672-1681.
Raman N, Lee M-R, Lynn DM, Palecek SP. Antifungal activity of 14-helical β-peptides against planktonic cells and biofilms of Candida Species. Pharmaceuticals. 2015;8:483-503.
Kratochvil MJ, Tal-Gan Y, Yang T, Blackwell HE, Lynn DM. Nanoporous Superhydrophobic Coatings that Promote the Extended Release of Water-Labile Quorum Sensing Inhibitors and Enable Long-Term Modulation of Quorum Sensing in Staphylococcus aureus. ACS Biomater. Sci. Eng. 2015;1:1039-1049.
Lee MR, Raman N, Gellman SH, Lynn DM, Palecek SP. Hydrophobicity and Helicity Regulate the Antifungal Activity of 14-Helical beta-Peptides. ACS Chemical Biology. 2014;9:1613-1621.
Muller JPE, Aytar BS, Kondo Y, Lynn DM, Abbott NL. Influence of the phase state of self-assembling redox mediators on their electrochemical activity. AIChE Journal. 2014;60:1381-1392.
Raman N, Lee MR, Palecek SP, Lynn DM. Polymer multilayers loaded with antifungal beta-peptides kill planktonic Candida albicans and reduce formation of fungal biofilms on the surfaces of flexible catheter tubes. Journal of Controlled Release. 2014;191:54-62.
Speetjens FW, Carter MCD, Kim M, Gopalan P, Mahanthappa MK, Lynn DM. Post-Fabrication Placement of Arbitrary Chemical Functionality on Microphase-Separated Thin Films of Amine-Reactive Block Copolymers. Acs Macro Letters. 2014;3:1178-1182.
Carlton RJ, Zayas-Gonzalez YM, Manna U, Lynn DM, Abbott NL. Surfactant-Induced Ordering and Wetting Transitions of Droplets of Thermotropic Liquid Crystals "Caged" Inside Partially Filled Polymeric Capsules. Langmuir. 2014;30:14944-14953.
Broderick AH, Stacy DM, Tal-Gan Y, Kratochvil MJ, Blackwell HE, Lynn DM. Surface Coatings that Promote Rapid Release of Peptide-Based AgrC Inhibitors for Attenuation of Quorum Sensing in Staphylococcus aureus. Adv. Healthcare Mater. 2014;3:97-105.
Manna U, Carter MCD, Lynn DM. "Shrink-to-Fit" Superhydrophobicity: Thermally-Induced Microscale Wrinkling of Thin Hydrophobic Multilayers Fabricated on Flexible Shrink-Wrap Substrates. Advanced Materials. 2013;25:3085-3089.
Manna U, Zayas-Gonzalez YM, Carlton RJ, Caruso F, Abbott NL, Lynn DM. Liquid Crystal Chemical Sensors That Cells Can Wear. Angewandte Chemie-International Edition. 2013;52:14011-14015.
Manna U, Lynn DM. Patterning and Impregnation of Superhydrophobic Surfaces Using Aqueous Solutions. ACS Applied Materials & Interfaces. 2013;5:7731-7736.
Saurer EM, Jewell CM, Roenneburg DA, Bechler SL, Torrealba JR, Hacker TA, et al.. Polyelectrolyte Multi layers Promote Stent-Mediated Delivery of DNA to Vascular Tissue. Biomacromolecules. 2013;14:1696-1704.
Tocce EJ, Liliensiek SJ, Broderick AH, Jiang Y, Murphy KC, Murphy CJ, et al.. The influence of biomimetic topographical features and the extracellular matrix peptide RGD on human corneal epithelial contact guidance. Acta Biomaterialia. 2013;9:5040-5051.
Yerushalmi SM, Buck ME, Lynn DM, Lemcoff NG, Meijler MM. Multivalent alteration of quorum sensing in Staphylococcus aureus. Chemical Communications. 2013;49:5177-5179.
Aytar BS, Muller JPE, Kondo Y, Abbott NL, Lynn DM. Spatial Control of Cell Transfection Using Soluble or Solid-Phase Redox Agents and a Redox-Active Ferrocenyl Lipid. ACS Applied Materials & Interfaces. 2013;5:8283-8288.
Aytar BS, Muller JPE, Kondo Y, Talmon Y, Abbott NL, Lynn DM. Redox-Based Control of the Transformation and Activation of siRNA Complexes in Extracellular Environments Using Ferrocenyl Lipids. Journal of the American Chemical Society. 2013;135:9111-9120.
Bechler SL, Si Y, Yu Y, Ren J, Liu B, Lynn DM. Reduction of intimal hyperplasia in injured rat arteries promoted by catheter balloons coated with polyelectrolyte multilayers that contain plasmid DNA encoding PKC delta. Biomaterials. 2013;34:226-236.
Broderick AH, Breitbach AS, Frei R, Blackwell HE, Lynn DM. Surface-Mediated Release of a Small-Molecule Modulator of Bacterial Biofilm Formation: A Non-Bactericidal Approach to Inhibiting Biofilm Formation in Pseudomonas aeruginosa. Adv. Healthcare Mater. 2013;2:993-1000.
Broderick AH, Carter MCD, Lockett MR, Smith LM, Lynn DM. Fabrication of Oligonucleotide and Protein Arrays on Rigid and Flexible Substrates Coated with Reactive Polymer Multilayers. ACS Applied Materials & Interfaces. 2013;5:351-359.
Broderick AH, Lynn DM. Covalent layer-by-layer assembly using reactive polymers. Funct. Polym. Post-Polym. Modif. 2013;:371-406.
Manna U, Kratochvil MJ, Lynn DM. Superhydrophobic Polymer Multilayers that Promote the Extended, Long-Term Release of Embedded Water-Soluble Agents. Adv. Mater. (Weinheim, Ger.). 2013;25:6405-6409.
Aytar BS, Muller JPE, Golan S, Hata S, Takahashi H, Kondo Y, et al.. Addition of ascorbic acid to the extracellular environment activates lipoplexes of a ferrocenyl lipid and promotes cell transfection. Journal of Controlled Release. 2012;157:249-259.
Aytar BS, Muller JPE, Golan S, Kondo Y, Talmon Y, Abbott NL, et al.. Chemical oxidation of a redox-active, ferrocene-containing cationic lipid: Influence on interactions with DNA and characterization in the context of cell transfection. Journal of Colloid and Interface Science. 2012;387:56-64.
Aytar BS, Prausnitz MR, Lynn DM. Rapid Release of Plasmid DNA from Surfaces Coated with Polyelectrolyte Multilayers Promoted by the Application of Electrochemical Potentials. ACS Applied Materials & Interfaces. 2012;4:2726-2734.
Bechler SL, Lynn DM. Characterization of Degradable Polyelectrolyte Multilayers Fabricated Using DNA and a Fluorescently-Labeled Poly(beta-amino ester): Shedding Light on the Role of the Cationic Polymer in Promoting Surface-Mediated Gene Delivery. Biomacromolecules. 2012;13:542-552.
Bechler SL, Lynn DM. Reactive Polymer Multi layers Fabricated by Covalent Layer-by-Layer Assembly: 1,4-Conjugate Addition-Based Approaches to the Design of Functional Biointerfaces. Biomacromolecules. 2012;13:1523-1532.
Broderick AH, Lockett MR, Buck ME, Yuan Y, Smith LM, Lynn DM. In situ Synthesis of Oligonucleotide Arrays on Surfaces Coated with Crosslinked Polymer Multilayers. Chemistry of Materials. 2012;24:938-945.
Manna U, Broderick AH, Lynn DM. Chemical Patterning and Physical Refinement of Reactive Superhydrophobic Surfaces. Advanced Materials. 2012;24:4291-+.
Muller JPE, Aytar BS, Kondo Y, Lynn DM, Abbott NL. Incorporation of DOPE into lipoplexes formed from a ferrocenyl lipid leads to inverse hexagonal nanostructures that allow redox-based control of transfection in high serum. Soft Matter. 2012;8:2608-2619.
Tocce EJ, Broderick AH, Murphy KC, Liliensiek SJ, Murphy CJ, Lynn DM, et al.. Functionalization of reactive polymer multilayers with RGD and an antifouling motif: RGD density provides control over human corneal epithelial cell-substrate interactions. Journal of Biomedical Materials Research Part A. 2012;100A:84-93.
Buck ME, Lynn DM. Azlactone-functionalized polymers as reactive platforms for the design of advanced materials: Progress in the last ten years. Polymer Chemistry. 2012;3:66-80.
Broderick AH, Manna U, Lynn DM. Covalent Layer-by-Layer Assembly of Water-Permeable and Water-Impermeable Polymer Multilayers on Highly Water-Soluble and Water-Sensitive Substrates. Chemistry of Materials. 2012;24:1786-1795.
Bechler SL, Lynn DM. Design and Synthesis of a Fluorescently End-Labeled Poly(beta-amino ester): Application to the Characterization of Degradable Polyelectrolyte Multilayers. Journal of Polymer Science Part a-Polymer Chemistry. 2011;49:1572-1581.
Broderick AH, Azarin SM, Buck ME, Palecek SP, Lynn DM. Fabrication and Selective Functionalization of Amine-Reactive Polymer Multi layers on Topographically Patterned Microwell Cell Culture Arrays. Biomacromolecules. 2011;12:1998-2007.
Buck ME, Lynn DM. Layer-by-Layer Fabrication of Covalently Crosslinked and Reactive Polymer Multilayers Using Azlactone-Functionalized Copolymers: A Platform for the Design of Functional Biointerfaces. Advanced Engineering Materials. 2011;13:B343-B352.
Flessner RM, Jewell CM, Anderson DG, Lynn DM. Degradable Polyelectrolyte Multilayers that Promote the Release of siRNA. Langmuir. 2011;27:7868-7876.
Golan S, Aytar BS, Muller JPE, Kondo Y, Lynn DM, Abbott NL, et al.. Influence of Biological Media on the Structure and Behavior of Ferrocene-Containing Cationic Lipid/DNA Complexes Used for DNA Delivery. Langmuir. 2011;27:6615-6621.
Saurer EM, Flessner RM, Buck ME, Lynn DM. Fabrication of covalently crosslinked and amine-reactive microcapsules by reactive layer-by-layer assembly of azlactone-containing polymer multilayers on sacrificial microparticle templates. Journal of Materials Chemistry. 2011;21:1736-1745.
Saurer EM, Yamanouchi D, Liu B, Lynn DM. Delivery of plasmid DNA to vascular tissue in vivo using catheter balloons coated with polyelectrolyte multilayers. Biomaterials. 2011;32:610-618.
Sun B, Flessner RM, Saurer EM, Jewell CM, Fredin NJ, Lynn DM. Characterization of pH-induced changes in the morphology of polyelectrolyte multilayers assembled from poly(allylamine) and low molecular weight poly(acrylic acid). Journal of Colloid and Interface Science. 2011;355:431-441.
Breitbach AS, Broderick AH, Jewell CM, Gunasekaran S, Lin Q, Lynn DM, et al.. Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity. Chemical Communications. 2011;47:370-372.
Buck ME, Lynn DM. Reactive Layer-by-Layer Assembly of Suspended Thin Films and Semipermeable Membranes at Interfaces Created Between Aqueous and Organic Phases. Advanced Materials. 2010;22:994-+.
Buck ME, Lynn DM. Functionalization of Fibers Using Azlactone-Containing Polymers: Layer-by-Layer Fabrication of Reactive Thin Films on the Surfaces of Hair and Cellulose-Based Materials. ACS Applied Materials & Interfaces. 2010;2:1421-1429.
Buck ME, Lynn DM. Free-Standing and Reactive Thin Films Fabricated by Covalent Layer-by-Layer Assembly and Subsequent Lift-Off of Azlactone-Containing Polymer Multilayers. Langmuir. 2010;26:16134-16140.
Buck ME, Schwartz SC, Lynn DM. Superhydrophobic Thin Films Fabricated by Reactive Layer-by-Layer Assembly of Azlactone-Functionalized Polymers. Chemistry of Materials. 2010;22:6319-6327.
Flessner RM, Yu Y, Lynn DM. Rapid release of plasmid DNA from polyelectrolyte multilayers: A weak poly(acid) approach. Chemical Communications. 2010;47:550-552.
Fredin NJ, Flessner RM, Jewell CM, Bechler SL, Buck ME, Lynn DM. Characterization of Nanoscale Transformations in Polyelectrolyte Multilayers Fabricated From Plasmid DNA Using Laser Scanning Confocal Microscopy in Combination With Atomic Force Microscopy. Microscopy Research and Technique. 2010;73:834-844.
Karlsson AJ, Flessner RM, Gellman SH, Lynn DM, Palecek SP. Polyelectrolyte Multilayers Fabricated from Antifungal beta-Peptides: Design of Surfaces that Exhibit Antifungal Activity Against Candida albicans. Biomacromolecules. 2010;11:2321-2328.
Kinsinger MI, Buck ME, Abbott NL, Lynn DM. Immobilization of Polymer-Decorated Liquid Crystal Droplets on Chemically Tailored Surfaces. Langmuir. 2010;26:10234-10242.
Kinsinger MI, Buck ME, Meli M-V, Abbott NL, Lynn DM. Langmuir films of flexible polymers transferred to aqueous/liquid crystal interfaces induce uniform azimuthal alignment of the liquid crystal. Journal of Colloid and Interface Science. 2010;341:124-135.
Saurer EM, Flessner RM, Sullivan SP, Prausnitz MR, Lynn DM. Layer-by-Layer Assembly of DNA- and Protein-Containing Films on Microneedles for Drug Delivery to the Skin. Biomacromolecules. 2010;11:3136-3143.
Sun B, Liu X, Buck ME, Lynn DM. Azlactone-functionalized polymers as reactive templates for parallel polymer synthesis: synthesis and screening of a small library of cationic polymers in the context of DNA delivery. Chemical Communications. 2010;46:2016-2018.
Sun B, Lynn DM. Release of DNA from polyelectrolyte multilayers fabricated using 'charge-shifting' cationic polymers: Tunable temporal control and sequential, multi-agent release. Journal of Controlled Release. 2010;148:91-100.
Buck ME, Breitbach AS, Belgrade SK, Blackwell HE, Lynn DM. Chemical Modification of Reactive Multilayered Films Fabricated from Poly(2-alkenyl azlactone)s: Design of Surfaces that Prevent or Promote Mammalian Cell Adhesion and Bacterial Biofilm Growth. Biomacromolecules. 2009;10:1564-1574.
Fredin NJ, Broderick AH, Buck ME, Lynn DM. Nanoimprinted Thin Films of Reactive, Azlactone-Containing Polymers: Combining Methods for the Topographic Patterning of Cell Substrates with Opportunities for Facile Post-Fabrication Chemical Functionalization. Biomacromolecules. 2009;10:994-1003.
Saurer EM, Jewell CM, Kuchenreuther JM, Lynn DM. Assembly of erodible, DNA-containing thin films on the surfaces of polymer microparticles: Toward a layer-by-layer approach to the delivery of DNA to antigen-presenting cells. Acta Biomaterialia. 2009;5:913-924.
Liu XH, Zhang JT, Lynn DM. Ultrathin Multilayered Films that Promote the Release of Two DNA Constructs with Separate and Distinct Release Profiles. Advanced Materials. 2008;20:4148-+.
Liu XH, Zhang JT, Lynn DM. Polyelectrolyte multilayers fabricated from 'charge-shifting' anionic polymers: a new approach to controlled film disruption and the release of cationic agents from surfaces. Soft Matter. 2008;4:1688-1695.
Liu X, Yang JW, Lynn DM. Addition of "Charge-Shifting" side chains to linear poly(ethyleneimine) enhances cell transfection efficiency. Biomacromolecules. 2008;9:2063-2071.
Kinsinger MI, Buck ME, Campos F, Lynn DM, Abbott NL. Dynamic Ordering Transitions of Liquid Crystals Driven by Interfacial Complexes Formed between Polyanions and Amphiphilic Polyamines. Langmuir. 2008;24:13231-13236.
Jewell CM, Lynn DM. Surface-mediated delivery of DNA: Cationic polymers take charge. Current Opinion in Colloid & Interface Science. 2008;13:395-402.
Jewell CM, Hays ME, Kondo Y, Abbott NL, Lynn DM. Chemical Activation of Lipoplexes Formed from DNA and a Redox-Active, Ferrocene-Containing Cationic Lipid. Bioconjugate Chemistry. 2008;19:2120-2128.
Jewell CA, Lynn DM. Multilayered polyelectrolyte assemblies as platforms for the delivery of DNA and other nucleic acid-based therapeutics. Advanced Drug Delivery Reviews. 2008;60:979-999.
Pizzey CL, Jewell CM, Hays ME, Lynn DM, Abbott NL, Kondo Y, et al.. Characterization of the nanostructure of complexes formed by a redox-active cationic lipid and DNA. Journal of Physical Chemistry B. 2008;112:5849-5857.
Buck ME, Zhang J, Lynn DM. Layer-by-layer assembly of reactive ultrathin films mediated by click-type reactions of poly(2-alkenyl azlactone)s. Advanced Materials. 2007;19:3951-+.
Jewell CM, Fuchs SM, Flessner RM, Raines RT, Lynn DM. Multilayered films fabricated from an oligoarginine-conjugated protein promote efficient surface-mediated protein transduction. Biomacromolecules. 2007;8:857-863.
Kinsinger ML, Sun B, Abbott NL, Lynn DM. Reversible control of ordering transitions at aqueous/liquid crystal interfaces using functional amphiphilic polymers. Advanced Materials. 2007;19:4208-+.
Lynn DM. Peeling back the layers: Controlled erosion and triggered disassembly of multilayered polyelectrolyte thin films. Advanced Materials. 2007;19:4118-4130.
Sun B, Jewell CM, Fredin NJ, Lynn DM. Assembly of multilayered films using well-defined, end-labeled poly(acrylic acid): Influence of molecular weight on exponential growth in a synthetic weak polyelectrolyte system. Langmuir. 2007;23:8452-8459.
Fredin NJ, Zhang J, Lynn DM. Nanometer-scale decomposition of ultrathin multilayered polyelectrolyte films. Langmuir. 2007;23:2273-2276.
Hays ME, Jewell CM, Lynn DM, Abbott NL. Reversible condensation of DNA using a redox-active surfactant. Langmuir. 2007;23:5609-5614.
Hays ME, Jewell CM, Kondo Y, Lynn DM, Abbott NL. Lipoplexes formed by DNA and ferrocenyl lipids: Effect of lipid oxidation state on size, internal dynamics, and zeta-potential. Biophysical Journal. 2007;93:4414-4424.
Zhang J, Fredin NJ, Lynn DM. Apparent dewetting of ultrathin multilayered polyelectrolyte films incubated in aqueous environments. Langmuir. 2007;23:11603-11610.
Zhang J, Lynn DM. Ultrathin multilayered films assembled from "Charge-Shifting" cationic polymers: Extended, long-term release of plasmid DNA from surfaces. Advanced Materials. 2007;19:4218-+.
Zhang J, Montanez SI, Jewell CM, Lynn DM. Multilayered films fabricated from plasmid DNA and a side-chain functionalized poly(beta-amino ester): Surface-type erosion and sequential release of multiple plasmid constructs-from surfaces. Langmuir. 2007;23:11139-11146.
Zhang JT, Fredin NJ, Lynn DM. Erosion of multilayered films fabricated from degradable polyamines: Characterization and evidence in support of a mechanism that involves polymer hydrolysis. Journal of Polymer Science Part a-Polymer Chemistry. 2006;44:5161.
Zhang JT, Fredin NJ, Janz JF, Sun B, Lynn DM. Structure/property relationships in erodible multilayered films: Influence of polycation structure on erosion profiles and the release of anionic polyelectrolytes. Langmuir. 2006;22:239-245.
Zhang J, Lynn DM. Multilayered films fabricated from combinations of degradable polyamines: Tunable erosion and release of anionic polyelectrolytes. Macromolecules. 2006;39:8928-8935.
Wood KC, Chuang HF, Batten RD, Lynn DM, Hammond PT. Controlling interlayer diffusion to achieve sustained, multiagent delivery from layer-by-layer thin films. Proceedings of the National Academy of Sciences of the United States of America. 2006;103:10207.
Jewell CM, Zhang JT, Fredin NJ, Wolff MR, Hacker TA, Lynn DM. Release of plasmid DNA from intravascular stents coated with ultrathin multilayered polyelectrolyte films. Biomacromolecules. 2006;7:2483.
Jewell CM, Hays ME, Kondo Y, Abbott NL, Lynn DM. Ferrocene-containing cationic lipids for the delivery of DNA: Oxidation state determines transfection activity. Journal of Controlled Release. 2006;112:129-138.
Lynn DM. Layers of opportunity: nanostructured polymer assemblies for the delivery of macromolecular therapeutics. Soft Matter. 2006;2:269-273.
Lynn DM, Anderson DG, Akinc A, Langer R. Degradable poly(beta-amino ester)s for gene delivery. In: Amiji MM. Polymeric Gene Delivery: Principles And Applications. CRC Press; 2005. pp. 227-241.
Little SR, Lynn DM, Puram SV, Langer R. Formulation and characterization of poly (beta amino ester) microparticles for genetic vaccine delivery. Journal of Controlled Release. 2005;107:449-462.
Jewell CM, Zhang JT, Fredin NJ, Lynn DM. Multilayered polyelectrolyte films promote the direct and localized delivery of DNA to cells. Journal of Controlled Release. 2005;106:214-223.
Abbott NL, Jewell CM, Hays ME, Kondo Y, Lynn DM. Ferrocene-containing cationic lipids: Influence of redox state on cell transfection. Journal of the American Chemical Society. 2005;127:11576-11577.
Liu XH, Yang JW, Miller AD, Nack EA, Lynn DM. Charge-shifting cationic polymers that promote self-assembly and self-disassembly with DNA. Macromolecules. 2005;38:7907-7914.
Wood KC, Boedicker JQ, Lynn DM, Hammon PT. Tunable drug release from hydrolytically degradable layer-by-layer thin films. Langmuir. 2005;21:1603-1609.
Fredin NJ, Zhang JT, Lynn DM. Surface analysis of erodible multilayered polyelectrolyte films: Nanometer-scale structure and erosion profiles. Langmuir. 2005;21:5803-5811.
Little SR, Lynn DM, Ge Q, Anderson DG, Puram SV, Chen JZ, et al.. Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines. Proceedings of the National Academy of Sciences of the United States of America. 2004;101:9534-9539.
Berry D, Lynn DM, Sasisekharan R, Langer R. Poly(beta-amino ester)s promote cellular uptake of heparin and cancer cell death. Chemistry & Biology. 2004;11:487-498.
Zhang JT, Chua LS, Lynn DM. Multilayered thin films that sustain the release of functional DNA under physiological conditions. Langmuir. 2004;20:8015-8021.
Gelman MA, Weisblum B, Lynn DM, Gellman SH. Biocidal activity of polystyrenes that are cationic by virtue of protonation. Organic Letters. 2004;6:557-560.
Potineni A, Lynn DM, Langer R, Amiji MM. Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive biodegradable system for paclitaxel delivery. Journal of Controlled Release. 2003;86:223-234.
Vazquez E, Dewitt DM, Hammond PT, Lynn DM. Construction of hydrolytically degradable thin films via layer-by-layer deposition of degradable polyelectrolytes (vol 124, pg 13992, 2002). Journal of the American Chemical Society. 2003;125:11452.
Akinc A, Lynn DM, Anderson DG, Langer R. Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery. Journal of the American Chemical Society. 2003;125:5316-5323.
Akinc A, Anderson DG, Lynn DM, Langer R. Synthesis of poly(beta-amino ester)s optimized for highly effective gene delivery. Bioconjugate Chemistry. 2003;14:979-988.
Vazquez E, Dewitt DM, Hammond PT, Lynn DM. Construction of hydrolytically-degradable thin films via layer-by-layer deposition of degradable polyelectrolytes. Journal of the American Chemical Society. 2002;124:13992-13993.
Zelikin AN, Lynn DM, Farhadi J, Martin I, Shastri V, Langer R. Erodible conducting polymers for potential biomedical applications. Angewandte Chemie-International Edition. 2002;41:141-144.
LaVan DA, Lynn DM, Langer R. Moving smaller in drug discovery and delivery. Nature Reviews. 2002;Drug Discovery. 1:77-84.
Lynn DM, Grubbs RH. Novel Reactivity of Ruthenium Alkylidenes in Protic Solvents: Degenerate Alkylidene Proton Exchange. Journal of the American Chemical Society. 2001;123:3187-3193.
Lynn DM, Anderson DG, Putnam D, Langer R. Accelerated Discovery of Synthetic Transfection Vectors: Parallel Synthesis and Screening of a Degradable Polymer Library. Journal of the American Chemical Society. 2001;123:8155-8156.
Lynn DM, Amiji MM, Langer R. pH-responsive polymer microspheres: Rapid release of encapsulated material within the range of intracellular pH. Angewandte Chemie-International Edition. 2001;40:1707-1710.
Lynn DM, Mohr B, Grubbs RH, Henling LM, Day MW. Water-soluble ruthenium alkylidenes: Synthesis, characterization, and application to olefin metathesis in protic solvents. Journal of the American Chemical Society. 2000;122:6601-6609.
Lynn DM, Langer R. Degradable poly(beta-amino esters): Synthesis, characterization, and self-assembly with plasmid DNA. Journal of the American Chemical Society. 2000;122:10761-10768.
Kirkland TA, Lynn DM, Grubbs RH. Ring-closing metathesis in methanol and water. Journal of Organic Chemistry. 1998;63:9904-9909.
Lynn DM, Mohr B, Grubbs RH. Living ring-opening metathesis polymerization in water. Journal of the American Chemical Society. 1998;120:1627-1628.
Grubbs RH, Lynn DM. Olefin metathesis. Aqueous-Phase Organomet. Catal. 1998;:466-476.
Lynn DM, Kanaoka S, Grubbs RH. Living ring-opening metathesis polymerization in aqueous media catalyzed by well-defined ruthenium carbene complexes. Journal of the American Chemical Society. 1996;118:784-790.
Mohr B, Lynn DM, Grubbs RH. Synthesis of water-soluble, aliphatic phosphines and their application to well-defined ruthenium olefin metathesis catalysts. Organometallics. 1996;15:4317-4325.