Department of Chemistry

College of Letters & Science
Jennifer Golden

Email address: jennifer.golden@wisc.edu

Room Number: 
7123 Rennebohm Hall
Telephone Number: 
Group Affiliation: 
Golden Group
Position Name: 
Assistant Professor

B.S. 1996, Eastern Illinois University
Ph.D. 2002, University of Kansas
Postdoctoral Research 2004, Stanford University

Also: Assistant Professor of Pharmaceutical Sciences
Associate Director, Medicinal Chemistry Center

golden's picture

Research Description

The Golden research group uses synthetic medicinal chemistry to address issues in chemical biology. We develop synthetic methodology to generate new chemical architecture and explore its associated pharmacology. Currently, projects in the Golden laboratory focus on chemical methodology development and the optimization of anti-infective and anticancer agents in cell and animal models. We work closely with expert collaborators who assess our compounds against various biological targets, and through structural manipulation of our chemical scaffolds, we refine properties to achieve a desired activity profile. Several projects are underway, and a few are represented below.

Project 1: Exploration of a novel quinazolinone rearrangement

We discovered that alpha-chloromethylquinazolinones, when treated with acyclic diamines, rearrange to form amidines. We explored the scope of this reaction as it relates to the electronics governing the susceptibility of the quinazolinone core to rearrange under multiple conditions. We further adapted the transformation to include the conversion of extended BOC-protected amino acids to the desired amidines through an efficient, telescoped sequence that integrates at least five chemical transformations in one pot!

Project 2: Development of anti-alphaviral agents with in vivo efficacy

Alphaviruses, RNA viruses spread most commonly by infected mosquitoes, can cause significant disease in animals and humans ranging from fever, rash, persistent arthritis, encephalitis and death. Though several of these agents are classified as bioterrorism threats, there are no FDA approved vaccines or drugs available for any alphavirus infection. Our laboratory has developed several compound classes that show efficacy against select alphaviruses in cells and in mice.

Project 3: Development of broad spectrum antiparasitic compounds

Our group has discovered three distinct structural classes that show broad spectrum inhibition of parasites related to malaria, African sleeping sickness and leishmaniasis. We have defined preliminary structure-activity relationships around each class and are now prepared to derive improved inhibitors for more advanced in vivo studies.

Selected Publications

Schroeder CE, Neuenswander SA, Yao T, Aube J, Golden JE. One-pot, regiospecific assembly of (E)-benzamidines from delta- and gamma-amino acids via an intramolecular aminoquinazolinone rearrangement. Organic & Biomolecular Chemistry. 2016;14:3950-3955.
Hong L, Guo Y, BasuRay S, Agola JO, Romero E, Simpson DS, et al. A Pan-GTPase Inhibitor as a Molecular Probe. Plos One. 2015;10:e0134317.
Schreiber SL, Kotz JD, Li M, Aube J, Austin CP, Reed JC, et al. Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell. 2015;161:1252-1265.
Chung DH, Jonsson CB, Tower NA, Chu YK, Sahin E, Golden JE, et al. Discovery of a Novel Compound with Anti-Venezuelan Equine Encephalitis Virus Activity That Targets the Nonstructural Protein 2. Plos Pathogens. 2014;10:10.
Flaherty DP, Miller JR, Garshott DM, Hedrick M, Gosalia P, Li YJ, et al. Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response. Acs Medicinal Chemistry Letters. 2014;5:1278-1283.