Email address: firstname.lastname@example.org
B.A. 2009, Northwestern University
Ph.D. 2015, Massachusetts Institute of Technology
Poctdoctoral Researcher at University of California, Berkeley, 2015 - 2019
Enzyme-Mimicking Catalysis in Evolvable Three-Dimensional Scaffolds
Naturally occurring enzymes catalyze a remarkably wide range of reactions with excellent efficiency and selectivity under mild conditions, making them potentially useful for numerous applications. However, the applications of natural enzymes are limited because they are generally expensive, difficult to prepare on large scale, too specific in their activity, and prone to deactivation outside their host organisms. A long-standing challenge has been to develop synthetic enzyme-mimicking catalysts, but nearly all synthetic catalysts reported to date are orders of magnitude less efficient than natural enzymes, which contain pre-organized functional groups in flexible three-dimensional cavities that are challenging to replicate synthetically. By combining innovative three-dimensional cage-like architectures, combinatorial synthetic strategies, and biotechnology-inspired high-throughput screening, my group will seek to create highly efficient enzyme-mimicking catalysts.
This interdisciplinary research program—drawing from organic chemistry, biochemistry, inorganic chemistry, and materials—is expected to yield novel and practically useful catalysts and to provide fundamental insights into catalytic mechanisms. My group will explore diverse applications of these catalysts, including synthetic methodology, energy, environmental remediation, and diagnostics. The molecules and materials developed during this research will have applications beyond enzyme-mimicking catalysis, including targeted therapeutics, drug delivery, and chemical separations.
|Kinetics of cooperative CO(2)adsorption in diamine-appended variants of the metal-organic framework Mg-2(dobpdc). Chemical Science. 2020;11:6457-6471..|
|Directed Evolution of Split APEX2 Peroxidase. ACS Chemical Biology. 2019;14:619-635..|
|Unexpected Diffusion Anisotropy of Carbon Dioxide in the Metal-Organic Framework Zn-2(dobpdc). Journal of the American Chemical Society. 2018;140:1663-1673..|
|Overcoming double-step CO2 adsorption and minimizing water co-adsorption in bulky diamine-appended variants of Mg-2(dobpdc). Chemical Science. 2018;9:160-174..|
|Elucidating CO2 Chemisorption in Diamine-Appended Metal-Organic Frameworks. 2018;140:18016-18031..|