Department of Chemistry

College of Letters & Science
David Schwartz

Email address: schwartz@chem.wisc.edu

Room Number: 
5434 Biotech
Telephone Number: 
Group Affiliation: 
Schwartz Group
Position Name: 
Chemical Biology

B.A. 1976, Hampshire College
Ph.D. 1985, Columbia University

Also: Kellett Professor of Chemistry and Genetics

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Research Description

Our laboratory creates functional systems for many types of genome analysis engendering large data sets for providing scalable biological insights. For this purpose we investigate the biochemical and physical attributes of individual molecules or complexes because reduction of experimental scale terminates at the level of a single molecule. Single molecules are the ultimate analyte since they represent the pinnacle of miniaturization and, when systematically analyzed as ensembles, offer the greatest advantages for generation of large-scale data sets. Such large and often complex data sets are the currency of modern biological analysis requiring extensive statistical and informatic components for revealing biological stories. In this regard, we have incorporated these components into our single molecule systems allowing us to discover novel human genome polymorphisms and to know the detailed architecture of cancer genomes. The new systems we are developing are pushing us to understand molecular nanoconfinement in ways fostering development of fluidic devices that when combined with novel molecular labeling or detection schemes, will power personal genomics and offer new routes for grappling with the complexity inherent to all biological systems.

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Awards and Honors

Vilas Associates Award 2009
Kellett Mid-Career Faculty Researcher Award, University of Wisconsin-Madison 2002
Amgen Prize, American Society for Biochemistry and Molecular Biology 1995
Beckman Young Investigator Award, Arnold and Mable Beckman Foundation 1993
National Science Foundation Presidential Young Investigator Award 1990

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