Class Notes for Chem 636 (fall 2014): Intro to NMR spectroscopy

Syllabus

Lectures are Tuesdays at 8:50am in rm. 2311

1. Sept 2 - Introduction to Chem 636
   Grading & Miscellaneous Info
   
2. Sept 9 - Introduction to 1D NMR
   Lec Notes
   
3. Sept 16 - Shims, pulse programs, and stuff
   Lec Notes
   
4. Sept 23 - Rf, nutations, rotating frame, digitization
   Lec Notes,   nutations+T1 ,   rg clipping example
   
5. Sept 30 - digitization, signal-to-noise, NOE
   Lec Notes,   energy level diagrams for NOE
   
6. Oct 7 - Spin-echoes, PT (INEPT)
   Lec Notes,  spin echoes,  pulse sequence and enery level diagrams for PT
   
7. Oct 14 - PT conclusion
   Lec Notes,  nicotine 13C coupled,  pulse sequence and enery level diagrams for PT
   
8. Oct 21 - 2D Intro
   2D Intro,  quinine example,  COSY
   
9. Oct 28 - review midterm exam, finish 2D Intro (COSY)
   2D Intro was update 28Oct2014 
   
10. Nov 4 - 2D cosy tocsy
    Outline: s/n (end of 2D Intro), cosy schematic, lr-cosy example
    
11. Nov 11 - Tocsy, Heteronuc correlation, Assignments and Publishing
    Outline: tocsy schematic, tocsy example, quinine example, heteronuclear cosy
    
12. Nov 18 - 2D assignment example - quinine
    
13. Nov 25 - Tocsy-1D, Intro to NOEs
    Outline: 3-heptanone tocsy example, oligosaccharide tocsy example, Intro to NOEs 
    
14. Dec 2 - NOEs and ROEs
    Examples: methyl lacone, A08&A11; Concepts: Intro to NOEs , heteronuclear cosy
    

Homework Assignments

HW#1: Processing 1D NMR data using MNova

HW#2: 1H 1D NMR using a Bruker AC-300 (Athena)

HW#3: 1H 1D NMR using a Bruker Avance-400 (Artemis) running TopSpin3.2

HW#4: Spectral Windows and 13C Decoupled and Coupled Spectra (Persephone, Av500P)

HW#5: 13C Polarization Transfer (PT) Spectra (Callisto, Av500DCH)

HW#6: X-Nucleus NMR: 19F, 31P, and 119Sn

HW#7: Automation: IconNMR and VNMRJ

HW#8: 2D NMR: Homonuclear correlation, COSY

HW#9: 2D NMR: TOCSY, HSQC; assignments
 
HW#10: 2D NMR: HMBC, assignments, publishing NMR data
 
HW#11: T1 measurements; Selective 1D: Tocsy-1d
 
HW#12: Selective 1D: Noesy-1d and Roesy-1d