Biomolecules:
DNA 1

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In this module:

Introduction
Nucleotides
Polymerization of Nucleotides
Base Pairing 1
Base Pairing 2
Complementary Sequences
Replication

Nucleotides

As mentioned on the previous page, DNA is a polymer of nucleotides. Nucleotides are assembled from the 5-carbon sugar ribose (see the Carbohydrates module for a review of sugars and other carbohydrates). If the carbons on ribose are numbered from 1' to 5', ribose is modified in three ways in nucleotides.

Click on the step numbers below to see how ribose is modified in nucleotides. Click on the mouse at left to clear the images and text.

1.

A phosphate group is attached to the hydroxyl group on the 5' carbon. Occasionally, one or two additional phosphate groups are attached to form nucleotide di- or triphosphates.

2.

One of four nitrogen-containing aromatic bases is attached to the 1' carbon by a glycosidic bond.

3.

Instead of a hydroxyl group and a hydrogen atom, the 2' carbon has two hydrogen atoms.


The four bases found in DNA are called adenine (A), thymine (T), guanine (G) and cytosine (C). The structures of these bases are shown below.


At right is a structure of the nucleotide adenine. Click on the links below to see the ribose, the phosphate group, and the base. (If the image is too small at first, click the "Reset" button to start.)

Nucleotides